Amantadine → HCID 10267477, compound

Participants

Reaction Steps

To a stirred solution of (2S,5R)-1-(chloroacetyl)-5-ethynylpyrrolidine-2-carbonitrile (0.03 g, 0.20 mmol ) in acetonitrile (3 mL ) at room temperature under nitrogen was added 1-adamantanamine(0.06 g, 0.408 mmol ). The reaction mixture was stirred for two days and then concentrated under reduced pressure. The residue was flash chromatographed with 2% MeOH/CH2Cl2 to provide the titled compound. MS (DCI) m/z 312 (M+H)+.

Provenance & Evidence