Water → (1-hydroxymethyl-cyclopentyl)-carbamic Acid Benzyl Ester

Participants

Reaction Steps

To a stirred solution of 1-amino-1-cyclopentanemethanol (1.15 g, 10 mmol ) and NaHCO3 (0.84 g, 10 mmol) in acetone (14 mL)/water (14 mL) at room temperature was added benzyl succinimidyl carbonate (2.5 g, 10 mmol). The reaction mixture was stirred at room temperature for 18 hours, concentrated under reduced pressure and purified by flash chromatography with 3% methanol:dichloromethane to provide the titled compound. MS (DCI) m/z 250 (M+H)+.

Provenance & Evidence