Sodium borohydride → HCID 10045440, compound

Participants

Reaction Conditions

Reaction Steps

N-Formyl-1-methoxy-4-[4-methoxyphenylaminosulphonyl]-9H-carbazole (example 70) (0.1 g, 0.24 mM) was dissolved in 18 mL of 20% aqueous THF solution. The reaction mixture was cooled to 0° C. in an ice bath. To it was added NaBH4 (0.055 g, 1.45 mM) portion wise. The reaction mixture was stirred overnight Solvent was evaporated and the aqueous layer was extracted with EtOAc. The organic layer was washed with brine and dried over anh. Na2SO4. It was filtered and concentrated to yield the crude product. The crude product was purified over a silica gel column using EtOAc- hexane as a solvent system to yield the desired compound as a white semi-solid with a yield of 66% (0.062 g).

Provenance & Evidence