Sodium borohydride → HCID 10090317, compound

Participants

Reaction Conditions

Reaction Steps

N-Formyl-1-methoxy-4-[4-methylphenylaminosulphonyl]-9H-carbazole (example 72) (0.14 g, 0.35 mM) was dissolved in 15 mL of 20% aqueous THF solution. The reaction mixture was cooled to 0° C. in an ice bath. To it was added NaBH4 (0.08 g, 2.1 mM) portion wise. The reaction mixture was stirred for 4-5 hrs. Solvent was evaporated and the aqueous layer was extracted with EtOAc. The organic layer was washed with brine and dried over anh. Na2SO4. It was filtered and concentrated to yield the desired compound as a white solid with a yield of 99% (0.13 g). mp 199-203° C.

Provenance & Evidence