Sodium Hydroxide → HCID 69280107, compound

HRID 1293479Notes

Reaction equation

HRID 1293479 reaction equation
C[O:2][C:3]([C:5]1[C:17]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]([CH2:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[C:9]=2[C:8]([O:26][CH3:27])=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+]>CO>[F:25][C:22]1[CH:21]=[CH:20][C:19]([CH2:18][N:10]2[C:9]3[C:8]([O:26][CH3:27])=[CH:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69282806HCID 69282806, compound

Product 1

HCID 69280107HCID 69280107, compoundYield 89.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 9-(4-fluoro benzyl)-1-methoxy-4-carbazole carboxylic acid methyl ester (490 mg, 1.35 mmoles) in methanol (15 ml), an aqueous (10 ml) solution of sodium hydroxide (108 mg, 2.7 mmoles) was added and the reaction mixture was refluxed for 6 hours. Methanol was evaporated from the reaction mixture under reduced pressure, acidified the residue with 1N HCl and the precipitated product was filtered washed with water and dried under vacuum, to give 420 mg of the title product

Workup

  1. temperaturethe reaction mixture was refluxed for 6 hours
  2. customMethanol was evaporated from the reaction mixture under reduced pressure
  3. filtrationthe precipitated product was filtered
  4. washwashed with water
  5. customdried under vacuum

Sources & evidence

ORD record
ord-4543368687504c9f9bcf3e4d15aadeb1
Source dataset
uspto-grants-2007_07
Patent number
US07238725B2

Reaction notes

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