4-Nitrophenol → HCID 10256405, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 8-chloro-9-(4-Fluorobenzyl)-1-methoxy-9H-4-carbazole carboxylic acid (130 mg, 0.327 mmoles) in 10 mL dry chloroform, thionyl chloride (0.071 mL, 0.981 mmoles) was added followed by a drop of DMF. The reaction mixture was stirred for 1 hr at 25° C. under nitrogen atmosphere. To the reaction mixture, 4-nitrophenol (45.5 mg, 0.3272 mmoles) was added and the reaction mixture was stirred for 2 hrs. The reaction mixture was quenched in ice cold water (50 mL) and extracted with ethyl acetate (2×25 ml). Ethyl acetate layer was washed with sodium bicarbonate solution (2×25 mL), 1N HCl (2×25 mL) and with brine, dried over sodium sulphate and concentrated to give 150 mg of the title compound.

Provenance & Evidence