Pyridine → HCID 86607034, compound

HRID 1293490Notes

Reaction equation

HRID 1293490 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[S:9][C:10]3[CH:15]=[CH:14][C:13]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:12][C:11]=3[C:7]=2[C:6]([S:20](Cl)(=[O:22])=[O:21])=[CH:5][CH:4]=1.[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=1.N1C=CC=CC=1>CC(C)=O.O>[CH3:1][O:2][C:3]1[C:8]2[S:9][C:10]3[CH:15]=[CH:14][C:13]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:12][C:11]=3[C:7]=2[C:6]([S:20](=[O:22])(=[O:21])[NH:32][C:29]2[CH:30]=[CH:31][C:26]([O:25][CH3:24])=[CH:27][CH:28]=2)=[CH:5][CH:4]=1

Participants

6

Reactant 3

HCID 1049PyridineHCID 7732P-AnisidineHCID 86607035HCID 86607035, compound

Product 1

HCID 86607034HCID 86607034, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

To a solution of 4-methoxy-dibenzo[b,d]thiophene-1,8-disulfonylchloride (0.2 g, 0.49 mmols) from step 1 in dry acetone (10 ml) was added p-anisidine (0.6 g, 0.49 mmols) and pyridine (0.06 g, 0.73 mmols). The reaction mixture was stirred at room temperature for 18 hrs. Acetone was evaporated and reaction mixture was diluted with water and extracted in ethyl acetate. Ethyl acetate layer on concentration gave crude product which was purified by silica gel column chromatography to get the pure product.

Workup

  1. customAcetone was evaporated
  2. customreaction mixture
  3. extractionextracted in ethyl acetate
  4. concentrationEthyl acetate layer on concentration
  5. customgave crude product which
  6. customwas purified by silica gel column chromatography
  7. customto get the pure product

Sources & evidence

ORD record
ord-29ae07032cf349398781525057ae1875
Source dataset
uspto-grants-2007_07
Patent number
US07238725B2

Reaction notes

Loading…