2,6-Diacetylpyridine → HCID 12143086, compound

Participants

Reaction Steps

2,6-Diacetylpyridine (1.76 g, 10.8 mmol) and 2,6-difluoroaniline (2.94 g, 22.8 mmol) were dissolved in 50 ml of toluene. To this solution, 4 Å molecular sieves were added. After standing for 3 days, with addition of more 4 Å molecular sieves the mixture was filtered. The solvent was removed in vacuo. The residue was crystallised from ethanol. Yield of 4: 1 g (24%). 1H-NMR (CDCl3) δ 8.44 (d, 2H, Py-Hm), 7.90 (t, 1H, Py-Hp), 7.05 (m, 2H, ArH) 6.96 (m, 4H, ArH), 2.44 (s, 6H, Me). 19F-NMR (CDCl3) δ −123.6.

Provenance & Evidence