Ethanolamine → 5-Bromo-2,4-difluoro-N-(2-hydroxyethyl)benzenesulfonamide

HRID 1293630Notes

Reaction equation

[Br:1][C:2]1[C:3]([F:13])=[CH:4][C:5]([F:12])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[CH2:14]([CH2:16][NH2:17])[OH:15]>>[Br:1][C:2]1[C:3]([F:13])=[CH:4][C:5]([F:12])=[C:6]([S:8]([NH:17][CH2:16][CH2:14][OH:15])(=[O:10])=[O:9])[CH:7]=1

Participants

Reactant 2

HCID 700Ethanolamine

HCID 27732965-bromo-2,4-difluorobenzenesulfonyl chloride

Product 1

HCID 670003525-Bromo-2,4-difluoro-N-(2-hydroxyethyl)benzenesulfonamideYield 100%

Procedure

Prepared by general procedure III from 5-bromo-2,4-difluorobenzene sulfonyl chloride (1.0 g, 3.4 mmol) and ethanolamine (231 mg, 3.77 mmol) to give the title compound (1.06 g, 100%) as an off-white solid. MS (ISP) 315.8 [(M+H)+].

Sources & evidence

ORD record: ord-f479468743f24b40a6d4b9f075d4d22a
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07238808B2

Reaction notes

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