Iodine chloride → 6-(4-Chloro-phenyl)-3-iodo-8-methyl-imidazo[1,2-a]pyridine

HRID 1293705Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([CH3:17])[C:11]3[N:12]([CH:14]=[CH:15][N:16]=3)[CH:13]=2)=[CH:4][CH:3]=1.[I:18]Cl>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH3:17])[C:11]3[N:12]([C:14]([I:18])=[CH:15][N:16]=3)[CH:13]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 24640Iodine chloride

HCID 670002626-(4-Chloro-phenyl)-8-methyl-imidazo[1,2-a]pyridine

Product 1

HCID 670006486-(4-Chloro-phenyl)-3-iodo-8-methyl-imidazo[1,2-a]pyridineYield 79%

Procedure

Prepared from 6-(4-chloro-phenyl)-8-methyl-imidazo[1,2-a]pyridine (example C.21 step 1) (6.65 g, 27 mmol) and iodine monochloride as described in example C.20 step 3. Obtained the title compound as an off-white solid (8.0 g, 79%). MS (ISP) 369.0 [(M+H)+], 371 [(M+2+H)+].

Sources & evidence

ORD record: ord-6d783987fc814d8d962653fd6536f870
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07238808B2

Reaction notes

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