Ethane, 2-bromo-1,1-diethoxy- → 6-Bromo-8-fluoroimidazo[1,2-a]pyridine

Participants

Reaction Steps

Prepared from 5-bromo-3-fluoro-pyridin-2-ylamine (example C.29 step 3) (3.1 g, 15.7 mmol) and bromoacetaldehyde diethyl acetal (90%, 4.86 mL, 31.3 mmol) as described in example C.20 step 1. Obtained the title compound as a light brown solid (3.0 g, 89%). MS (ISP) 215.1 [(M+H)+], 217.1 [(M+2+H)+].

Provenance & Evidence