Trimethylsilylacetylene → 5-Ethynylthiophene-2-sulfonamide

Participants

Reaction Steps

Prepared from 5-bromo-thiophene-2-sulfonic acid amide (1.94 g, 8 mmol) and trimethylsilylacetylene (2.2 mL, 12 mmol) by applying in analogous manner the procedures described in example D.1 (method 1, steps 1–2). Obtained after chromatographic purification of the crude product (SiO2, 0–75% AcOEt/heptane) as a light brown solid (0.49 g, 33%). MS (ISP) 186.1 [(M−H)−]; mp 114–116° C.

Provenance & Evidence