2-Chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiazole-5-sulfonamide → HCID 86608039, compound

HRID 1293797Notes

Reaction equation

HRID 1293797 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[N:17]3[N:24]=[CH:25][C:26]([C:27]#[CH:28])=[C:16]3[N:15]=2)[CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH3:2].[OH:29][CH2:30][C:31]([NH:34][S:35]([C:38]1[S:42][C:41](Cl)=[N:40][CH:39]=1)(=[O:37])=[O:36])([CH3:33])[CH3:32]>>[OH:29][CH2:30][C:31]([NH:34][S:35]([C:38]1[S:42][C:41]([C:28]#[C:27][C:26]2[CH:25]=[N:24][N:17]3[C:18]([C:20]([F:21])([F:22])[F:23])=[CH:19][C:14]([C:6]4[CH:7]=[CH:8][C:9]([C:10]([F:13])([F:11])[F:12])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=4)=[N:15][C:16]=23)=[N:40][CH:39]=1)(=[O:37])=[O:36])([CH3:33])[CH3:32]

Participants

3

Reactant 2

HCID 610526512-Chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiazole-5-sulfonamideHCID 86608040HCID 86608040, compound

Product 1

HCID 86608039HCID 86608039, compound

Procedure

The title compound was prepared from 5-(3-Ethoxy-4-trifluoromethyl-phenyl)-3-ethynyl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine (example C.3) (400 mg, 1.0 mmol) and 2-chloro-thiazole-5-sulfonic acid(2-hydroxy-1,1-dimethyl-ethyl)-amide (example B.14) (244 mg, 1.0 mmol) according to general procedure II. Obtained as an orange solid (80 mg, 12%). MS (ISP) 634.1[(M+H)+]; mp 209–211° C.

Sources & evidence

ORD record
ord-5d9d85e351af43638216e39dddae1d40
Source dataset
uspto-grants-2007_07
Patent number
US07238808B2

Reaction notes

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