3-Bromo-5-methoxypyridine → HCID 86608045, compound

HRID 1293803Notes

Reaction equation

HRID 1293803 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:9]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)=[N:8][C:7]=12)#[CH:2].Br[C:27]1[CH:28]=[C:29]([O:33][CH3:34])[CH:30]=[N:31][CH:32]=1>>[CH3:34][O:33][C:29]1[CH:28]=[C:27]([C:2]#[C:1][C:3]2[CH:4]=[N:5][N:6]3[C:11]([C:12]([F:14])([F:13])[F:15])=[CH:10][C:9]([C:16]4[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=4)=[N:8][C:7]=23)[CH:32]=[N:31][CH:30]=1

Participants

3

Reactant 2

HCID 8171633-Bromo-5-methoxypyridineHCID 715397323-Ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 86608045HCID 86608045, compound

Procedure

The title compound was prepared from 3-ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.1)(355 mg, 1.0 mmol) and commercially available 5-bromo-3-methoxypyridine (169 mg, 1.0 mmol) according to general procedure II. Obtained as a yellow solid (210 mg, 45%). MS (ISP) 463.2[(M+H)+]; mp 232–234° C.

Sources & evidence

ORD record
ord-5486f2704edd47ff87063c665975ee94
Source dataset
uspto-grants-2007_07
Patent number
US07238808B2

Reaction notes

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