Methyl Salicylate → HCID 10979618, compound

Participants

Reaction Steps

1.52 g of methyl salicylate, 2.33 g of 2-bromomethyl-4,6-dimethoxypyrimidine and 1.6 g of potassium carbonate were stirred in 20 ml of dimethylformamide at 60° C. for 2 hours. The reaction mixture was poured in ice water and extracted with ethyl acetate. The extract was dried over sodium sulfate and, after distilling off the solvent, purified using silica gel chromatography to obtain 2.5 g of methyl 2-(4,6-dimethoxy-2-pyrimidyl)methyloxybenzoate (yield 82%).

Provenance & Evidence