2-Pyridinamine, 5-bromo-6-methyl- → HCID 67001037, compound

HRID 1293884Notes

Reaction equation

HRID 1293884 reaction equation
[F:1][CH:2]([F:24])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]#[CH:13])=[C:7]2[N:6]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:4]=1.[NH2:25][C:26]1[N:31]=[C:30]([CH3:32])[C:29](Br)=[CH:28][CH:27]=1>>[F:24][CH:2]([F:1])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]#[C:13][C:29]3[CH:28]=[CH:27][C:26]([NH2:25])=[N:31][C:30]=3[CH3:32])=[C:7]2[N:6]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 1706782-Pyridinamine, 5-bromo-6-methyl-HCID 866080343-Ethynyl-7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 67001037HCID 67001037, compound

Procedure

The title compound was prepared from 7-difluoromethyl-3-ethynyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.2) (340 mg, 1.0 mmol) and 6-amino-3-bromo-2-methylpyridine (168 mg, 1.0 mmol) according to general procedure II. Obtained as a red solid (65 mg, 15%). MS (ISP) 444.3 [(M+H)+]; mp 243–246° C.

Sources & evidence

ORD record
ord-39ccc4db3fd248bf9235c1f37232f7af
Source dataset
uspto-grants-2007_07
Patent number
US07238808B2

Reaction notes

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