Potassium Hydroxide → HCID 19371424, compound

HRID 129390Notes

Reaction equation

HRID 129390 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([CH2:11][O:12][C:13]2[CH:22]=[CH:21][CH:20]=[CH:19][C:14]=2[C:15]([O:17]C)=[O:16])[N:4]=1.[OH-].[K+]>C(O)C.O>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([CH2:11][O:12][C:13]2[CH:22]=[CH:21][CH:20]=[CH:19][C:14]=2[C:15]([OH:17])=[O:16])[N:6]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 10979618HCID 10979618, compound

Product 1

HCID 19371424HCID 19371424, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

1.5 g of methyl 2-[(4,6-dimethoxy-2-pyrimidyl)methyloxy]benzoate was dissolved in 10 ml of ethanol. 10 ml of water and then 7 ml of 1N aqueous potassium hydroxide solution were added to this solution, and the mixture was stirred until it got to be clear (about 4 hours). The reaction solution was diluted with water and washed with ether, the water layer was neutralized with 1N hydrochloric acid and extracted with chloroform, the extract was dried over anhydrous magnesium sulfate, and the solvent was distilled off to obtain 1.3 g of 2-[(4,6-dimethoxy-2-pyrimidyl)methyloxy]benzoic acid (yield 91%).

Workup

  1. custom(about 4 hours)
  2. washwashed with ether
  3. extractionextracted with chloroform
  4. dry with materialthe extract was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-4a2d826bbed844f6a38ce9be040a65f8
Source dataset
uspto-grants-1995_11
Patent number
US05468721

Reaction notes

Loading…