反应详情

5.34 g (30 millimoles) of methyl 2-methylphenylglyoxylate and 5.34 g (30 millimoles) of N-bromosuccinimide in 1000 l of tetrachloromethane are exposed to a 300 W Hg vapor lamp for one hour. The organic phase is then washed once with water and three times with sodium bicarbonate solution and is dried over sodium sulfate/sodium carbonate. After the solution has been evaporated down, the crude product is chromatographed over silica gel using 1:9 methyl tert-butyl ether/n-hexane. 3.8 g (49%) of the abovementioned compound are obtained as a yellow oil.

1. washThe organic phase is then washed once with water and three times with sodium bicarbonate solution
2. dry with materialis dried over sodium sulfate/sodium carbonate
3. customAfter the solution has been evaporated down
4. customthe crude product is chromatographed over silica gel using 1:9 methyl tert-butyl ether/n-hexane