Sodium Hydroxide → HCID 9867315, compound

HRID 129395Notes

Reaction equation

HRID 129395 reaction equation
C[O:2][C:3](=[O:31])[C@H:4]([CH2:27][CH2:28][S:29][CH3:30])[NH:5][C:6](=[O:26])[C@H:7]([C@H:22]([CH2:24][CH3:25])[CH3:23])[NH:8][C:9](=[O:21])[C@H:10]([CH:18]([CH3:20])[CH3:19])[NH:11][C:12](=[O:17])[CH2:13][CH2:14][CH2:15]Cl.[OH-].[Na+]>CO>[N:11]1([C@@H:10]([CH:18]([CH3:20])[CH3:19])[C:9]([NH:8][C@H:7]([C:6]([NH:5][C@H:4]([C:3]([OH:2])=[O:31])[CH2:27][CH2:28][S:29][CH3:30])=[O:26])[C@H:22]([CH2:24][CH3:25])[CH3:23])=[O:21])[CH2:15][CH2:14][CH2:13][C:12]1=[O:17]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15283802HCID 15283802, compound

Product 1

HCID 9867315HCID 9867315, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product of Step A was suspended in 5 mL of methanol and 0.6 mL of 1N NaOH was added. After 1 h. the methanol was evaporated, the residue was dissolved in water and filtered. The filtrate was acidified and the product was extracted into ethyl acetate. After standard workup, a solid was obtained, which was washed with water and ether. After drying the solid weighed 25 mg. FAB mass spectrum m/z=430 (M+1).

Workup

  1. customAfter 1 h. the methanol was evaporated
  2. dissolutionthe residue was dissolved in water
  3. filtrationfiltered
  4. extractionthe product was extracted into ethyl acetate
  5. customAfter standard workup, a solid was obtained
  6. washwhich was washed with water and ether
  7. customAfter drying the solid

Sources & evidence

ORD record
ord-b10e077dffc8452fa087d8a15e7f4e16
Source dataset
uspto-grants-1995_11
Patent number
US05468733

Reaction notes

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