2-Amino-5-bromopyridine → HCID 67001126, compound

HRID 1293981Notes

Reaction equation

HRID 1293981 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[C:11]([CH:12]([F:14])[F:13])=[CH:10][C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=3)=[N:8][C:7]=12)#[CH:2].[NH2:25][C:26]1[N:31]=[CH:30][C:29](Br)=[CH:28][CH:27]=1>>[F:13][CH:12]([F:14])[C:11]1[N:6]2[N:5]=[CH:4][C:3]([C:1]#[C:2][C:29]3[CH:28]=[CH:27][C:26]([NH2:25])=[N:31][CH:30]=3)=[C:7]2[N:8]=[C:9]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:23])([F:24])[F:22])[CH:16]=2)[CH:10]=1

Participants

3

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 866080813-Ethynyl-7-difluoromethyl-5-(3-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 67001126HCID 67001126, compound

Procedure

The title compound was prepared from 3-ethynyl-7-difluoromethyl-5-(3-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.15) (169 mg, 0.5 mmol) and commercially available 6-amino-3-bromo-pyridine (87 mg, 0.5 mmol) according to general procedure II. Obtained as a red solid (48 mg, 22%). MS (EI) 429.1 [(M)+]; mp 164° C.

Sources & evidence

ORD record
ord-10db62f1d6b64b3c922ce855dc8e7c13
Source dataset
uspto-grants-2007_07
Patent number
US07238808B2

Reaction notes

Loading…