5-(4-Chloro-phenyl)-3-iodo-7-methyl-pyrazolo[1,5-a]pyrimidine → 2-(4-[5-(4-Chloro-phenyl)-7-methyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-propan-2-ol

Participants

Role	Name	HCID	Charge
Reactant	5-(4-Chloro-phenyl)-3-iodo-7-methyl-pyrazolo[1,5-a]pyrimidine	HCID 67001322	—
Reactant	2-(4-Ethynylphenyl)propan-2-ol	HCID 73012446	—
Product	2-(4-[5-(4-Chloro-phenyl)-7-methyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-propan-2-ol	HCID 11852217	47%

Reaction Steps

The tide compound was prepared from 5-(4-chloro-phenyl)-3-iodo-7-methyl-pyrazolo[1,5-a]pyrimidine (example 292) (185 mg, 0.5 mmol) and 2-(4-ethynyl-phenyl)-propan-2-ol (example D.4) (80 mg, 0.5 mmol) according to general procedure II. Obtained as a yellow solid (94 mg, 47%). MS (ISP) 402.3 [(M+H)+]; mp 112–115° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07238808B2
Source dataset	uspto-grants-2007_07
ORD ID	ord-a0562a866f71462caa927a21abf3b7e8
Source note	uspto-grants-2007_07