反应详情

Na2S2O4 (28.2 g, 160 mmol) was added to a solution of 5-(4-Acetamidophenoxy)-2-nitroaniline (Intermediate 1) (13.7 g, 48 mmol) in EtOH (600 ml) and H2O (150 ml). The yellow mixture was refluxed with vigorous stirring until the color disappeared. After cooling, the mixture was washed with brine and the product was extracted with AcOEt. The AcOEt layer was dried over MgSO4, filtered and evaporated to give intermediate 2 as a brown film (10.2 g, 83%): MS m/e 258 (M+1).

1. temperatureThe yellow mixture was refluxed
2. temperatureAfter cooling
3. washthe mixture was washed with brine
4. extractionthe product was extracted with AcOEt
5. dry with materialThe AcOEt layer was dried over MgSO4
6. filtrationfiltered
7. customevaporated