HCID 17755138, compound → 1,2-Benzenediamine, 4-(4-aminophenoxy)-

Participants

Reaction Steps

Pd/C (5%, 3.0 g) was introduced to a solution of 5-(4-((2-Fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-2-nitroaniline (Intermediate 5) (21.6 g, 48 mmol) in ethanol (200 ml) under Ar. The starting material was hydrogenated under a H2 atmosphere for 3 days while being stirred. The reaction mixture was then filtered through celite and evaporated to give intermediate 6 as a black film. This crude material was chromatographed through silica gel (hexane-AcOEt, 4:1–3:1–2:1–1:1–0:1) to give purified intermediate 6 (13.0 g, 64%): MS m/e 421 (M+1).

Provenance & Evidence