Methyl (4-bromo-6-(4-nitrophenoxy)benzthiazole-2-yl)carbamate → Methyl (4-bromo-6-(4-aminophenoxy)benzthiazole-2-yl)carbamate

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Reaction Steps

To a solution of methyl (4-bromo-6-(4-nitrophenoxy)benzthiazole-2-yl)carbamate (Intermediate 10F-65.3 mg, 0.15 mmol) in AcOH (2 mL) was added Zn powder (300 mg) and stirred at room temperature for 2 hrs. The insoluble materials were removed by filtration. The solvent was removed by evaporation. The residue was charged on SCX column chromatography then washed with MeOH then eluted with NH3—MeOH to give the title compound (39.6 mg, 65%): MS m/e 394, 396 (M+1).

Provenance & Evidence