Methanol → HCID 178505075, compound

Participants

Reaction Steps

2-amino-5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazole (the product of Example 22–600 mg) and methanesulfonyl chloride (5 equiv.) in pyridine was stirred at room temperature for 2 days. The resulting mixture was treated with K2C03 (10 equiv.) and H2O (10 mL) and MeOH (10 mL), and heated at 60 C. for 7 days. The crude solid was collected by filtration. Recrystallization from hot MeOH afforded the title compound (280 mg, 40%);

Provenance & Evidence