HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-methyl-2-benzofuran-1(3H)-one → 2-{3-[2-(4-Fluorophenyl)oxazol-4-ylmethoxy]phenoxymethyl}-6-methylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-methyl-2-benzofuran-1(3H)-one | HCID 638757 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 3-[2-(4-Fluorophenyl)oxazol-4-ylmethoxy]phenol | HCID 69050169 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-{3-[2-(4-Fluorophenyl)oxazol-4-ylmethoxy]phenoxymethyl}-6-methylbenzoic acid | HCID 11407847 | — |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
1 g (6.8 mmol) of 7-methylphthalide and 2 g (7.0 mmol) of 3-[2-(4-fluorophenyl)oxazol-4 -ylmethoxy]phenol are dissolved in NMP. 3.9 ml of methanolic sodium methoxide (30% strength) are added, the methanol is distilled off, and the mixture is heated to 130° C. No formation of 2-{3-[2-(4-fluorophenyl)oxazol-4-ylmethoxy]phenoxymethyl}-6-methylbenzoic acid is observed. The 3-[2-(4-fluorophenyl)oxazol-4-ylmethoxy]phenol decomposes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07238835B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-6617fe5e24024e73ade8678dd71fb62b |
| Source note | uspto-grants-2007_07 |