Ethanol → HCID 17861281, compound

Participants

Reaction Steps

A mixture of ethyl (E)-3-(5-benzyloxy-2-ethoxyphenyl)-2-propenoate (1.85 g), 5% palladium carbon (3.0 g), ethanol (50 mL) and tetrahydrofuran (30 mL) was subjected to catalytic hydrogenation at room temperature and 1 atm. After filtering off the catalyst, the solvents were evaporated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give ethyl 3-(2-ethoxy-5-hydroxyphenyl)propionate as a colorless oil (1.30 g, 96%) from a fraction eluted with ethyl acetate-hexane (1:4, v/v).

Provenance & Evidence