HCID 17861278, compound → HCID 17861300, compound

HRID 1294101Notes

Reaction equation

HRID 1294101 reaction equation
COC[O:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:17][CH2:18][CH3:19])=[C:9]([CH:16]=1)[O:10][CH2:11][C:12]([O:14][CH3:15])=[O:13]>Cl.CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:17][CH2:18][CH3:19])=[C:9]([CH:16]=1)[O:10][CH2:11][C:12]([O:14][CH3:15])=[O:13]

Participants

3

Reactant 1

HCID 17861278HCID 17861278, compound

Product 1

HCID 17861300HCID 17861300, compoundYield 87.5%

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

A mixture of methyl 2-(5-methoxymethoxy-2-propylphenoxy)acetate (1.60 g) and 10% hydrogen chloride-methanol (50 mL) was stirred at room temperature for 3 hrs. The reaction mixture was concentrated, and ethyl acetate was added to the residue. The mixture was washed successively with saturated aqueous sodium hydrogencarbonate and saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give methyl 2-(5-hydroxy-2-propylphenoxy)acetate as a colorless oil (1.17 g, 87%).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionethyl acetate was added to the residue
  3. washThe mixture was washed successively with saturated aqueous sodium hydrogencarbonate and saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-3aed08c5440c43b488f4c8725fadf896
Source dataset
uspto-grants-2007_07
Patent number
US07238716B2

Reaction notes

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