Hydrochloric Acid → 4-(2-Phenyl-4-thiazolylmethoxy)benzyl alcohol

Participants

Reaction Steps

To a mixture of 4-[(2-phenyl-4-thiazolyl)methoxy]benzaldehyde (6.35 g), tetrahydrofuran (30 ml) and methanol (20 mL) was added sodium borohydride (0.45 g) under ice-cooling, and the mixture was stirred at room temperature for 30 min. Dilute hydrochloric acid and water were added to acidify the reaction mixture. The precipitated solid was collected by filtration, and dried with air to give crystals (5.76 g, 90%) of [4-[(2-phenyl-4-thiazolyl)methoxy]phenyl]methanol. Recrystallization from ethyl acetate-hexane gave colorless needle crystals. melting point: 145-146° C.

Provenance & Evidence