참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Hydroxybenzaldehyde | HCID 126 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Thiazole, 4-(chloromethyl)-5-methyl-2-phenyl- | HCID 12794636 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(5-Methyl-2-phenyl-4-thiazolylmethoxy)benzaldehyde | HCID 23025085 | 93% |
반응 단계
A mixture of 4-chloromethyl-5-methyl-2-phenylthiazole (5.40 g), 4-hydroxybenzaldehyde (2.91 g), anhydrous potassium carbonate (4.95 g) and N,N-dimethylformamide (50 mL) was stirred at 80° C. for 3 hrs. The reaction mixture was poured into water, and the precipitated solid was collected by filtration, and dried with air to give crystals (6.85 g, 93%) of 4-[(5-methyl-2-phenyl-4-thiazolyl)methoxy]benzaldehyde. Recrystallization from ethyl aceetate-hexane gave colorless prism crystals. melting point: 18-119° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07238716B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_07 |
|---|
| ORD ID | ord-89ac409cabab47bcbd0651b9610c8ed1 |
|---|
| 출처 메모 | uspto-grants-2007_07 |
|---|
