HCID 86760506, compound → HCID 17861374, compound

Participants

Reaction Steps

A mixture of ethyl (E)-3-(2-benzyloxy-5-ethoxyphenyl)-2-propenoate (4.58 g), 5% palladium carbon (6.0, g) and tetrahydrofuran (100 mL) was subjected to catalytic hydrogenation at room temperature and 1 atm. After filtering off the catalyst, the solvent was evaporated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give ethyl 3-(5-ethoxy-2-hydroxyphenyl)propionate as a colorless oil (3.15 g, 94%) from a fraction eluted with ethyl acetate-hexane (1:6, v/v).

Provenance & Evidence