Hydrochloric Acid → HCID 68883965, compound

Participants

Reaction Steps

To a mixture of methyl 2-[2-benzoyl-5-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]phenoxy]acetate (0.55 g), tetrahydrofuran (1.5 mL) and methanol (1.5 mL) was added a 1N aqueous sodium hydroxide solution (1.5 mL) and the mixture was stirred at room temperature for 3 hrs. 1N Hydrochloric acid and water were added to acidify the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give 2-[2-benzoyl-5-[4[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]phenoxy]acetic acid as a colorless amorphous compound (0.41 g, 76%).

Provenance & Evidence