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HRID129416

反应详情

EQUATION

反应方程式

HRID 129416 的结构方程式

REACTANTS

反应物

2
结构：CC#[C][Sn]([CH2]CCC)([CH2]CCC)[CH2]CCC
HCID2733165

Tributyl(1-propynyl)tin

C15H30Sn

结构：CCOC(=O)c1cn(C2CC2)c2c(Br)c(F)c(F)cc2c1=O
HCID11046932

未命名化合物

PRODUCTS

生成物

1
结构：CC#Cc1c(F)c(F)cc2c(=O)c(C(=O)OCC)cn(C3CC3)c12
HCID131719208

未命名化合物

收率 30.7%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

7.5 g of ethyl 8-bromo-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate, 9.1 g of 1-tributylstannyl-prop-1-ine and 1.16 g of tetrakis(triphenylphosphine)palladium(0) are refluxed for 8 hours in 80 ml of absolute toluene under a nitrogen atmosphere. The solid which crystallises out at -18° C. is filtered off with suction and dried. 2.05 g of ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-8-(propin-1-yl)-3-quinolinecarboxylate are obtained (31% of theory).

WORKUP

后处理

  1. customThe solid which crystallises out at -18° C.
  2. filtrationis filtered off with suction
  3. customdried