Sodium Hydroxide → HCID 17861327, compound

Participants

Reaction Steps

A mixture of [5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-pyridylmethyl]acetate (18.0 g), 1N aqueous sodium hydroxide solution (75 mL) and methanol (100 mL) was stirred at room temperature for 3 hrs. and concentrated. The residue was dissolved in ethyl acetate, washed with water and then with saturated brine, dried over anhydrous magnesium sulfate and concentrated. The obtained colorless crystals were collected by filtration to give 5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-pyridylmethanol (14.29 g, yield 91%). The crystals were recrystallized from ethyl acetate-hexane. melting point: 125-126° C.

Provenance & Evidence