HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyl alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 4-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde | HCID 18546159 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyl alcohol | HCID 68883359 | 95.4% |
Reaction Steps
To a mixture of 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde (6.00 g), tetrahydrofuran (80 mL) and methanol (20 mL) was gradually added sodium borohydride (330 mg) at room temperature. After stirring for 30 min., water was added to the reaction mixture, and the precipitated crystals were collected by filtration and recrystallized from acetone-methanol to give colorless prism crystals (5.76 g, 95%) of 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyl alcohol. melting point: 181-182° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07238716B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-81a421e52c1a488eaaff4402bbab01ec |
| Source note | uspto-grants-2007_07 |