Tetrahydrofuran → HCID 68883980, compound

Participants

Reaction Steps

To a mixture of 4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyl 2-[3-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]phenyl]acetate (2.40 g), tetrahydrofuran (7 mL) and ethanol (7 mL) was added 1N aqueous sodium hydroxide solution (7.0 mL) and the mixture was stirred overnight at room temperature. The reaction mixture was concentrated, and water and diethyl ether were added to the residue. Dilute hydrochloric acid was added to acidify the aqueous layer, and the precipitated solid was collected by filtration, and dried with air to give crystals (1.24 g, 85%) of 2-[3-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]phenyl]acetic acid. Recrystallization from acetone-hexane gave colorless prism crystals. melting point: 159-160° C.

Provenance & Evidence