Hydrochloric Acid → HCID 68885479, compound

Participants

Reaction Steps

A mixture of methyl 3-[2-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]phenyl]propionate (0.54 g), lithium hydroxide monohydrate (0.0743 g), tetrahydrofuran (6 mL), water (4 mL) and methanol (4 mL) was stirred at room temperature for 1.5 hrs. 1N Hydrochloric acid (1.8 mL) was added to acidify the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated to give crystals of 3-[2-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]phenyl]propionic acid. Recrystallization from ethyl acetate-hexane gave colorless prism crystals (0.49 g, 94%). melting point: 98-99° C.

Provenance & Evidence