Hydrochloric Acid → HCID 68884245, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of methyl 2-[2-[3-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]phenyl]acetate (0.50 g), tetrahydrofuran (2 mL) and methanol (2 mL) was added a 1N aqueous sodium hydroxide solution (2.0 mL) and the mixture was stirred at 50° C. for 1 hr. 1N Hydrochloric acid (2 mL) and water were added to acidify the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated: to give crystals (0.41 g, 87%) of 2-[2-[3-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]phenyl]acetic acid. Recrystallization from methyl acetate-hexane gave colorless prism crystals. melting point: 117-118° C.

Provenance & Evidence