Hydrochloric Acid → HCID 68884266, compound

Participants

Reaction Steps

To a mixture of 2-[3-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-2-pyridyl]acetonitrile (0.55 g), tetrahydrofuran (1 mL) and ethanol (4 mL) was added a 2N aqueous sodium hydroxide solution (4 mL) and the mixture was stirred with heating under reflux for 12 hrs. 1N Hydrochloric acid (8 mL) and water were added to the reaction mixture, and the precipitated solid was collected by filtration and dried with air to give crystals (0.35 g, 47%) of 2-[3-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-2-pyridyl]acetic acid. Recrystallization from tetrahydrofuran-hexane gave colorless prism crystals. melting point: 115-116° C. (dec.)

Provenance & Evidence