Hydrochloric Acid → HCID 68884132, compound

Participants

Reaction Steps

To a mixture of 2-[5-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-3-pyridyl]acetonitrile (0.66 g), tetrahydrofuran (1 mL) and ethanol (5 mL) was added a 2N aqueous sodium hydroxide solution (5 mL) and the mixture was stirred with heating under reflux for 8 hrs. 1N Hydrochloric acid (10 mL) and water were added to the reaction mixture, and the precipitated solid was collected by filtration and dried with air to give crystals (0.67 g, 97%) of 2-[5-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-3-pyridyl]acetic acid. Recrystallization from tetrahydrofuran-hexane gave pale-brown prism crystals. melting point: 139-140° C.

Provenance & Evidence