HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic Acid → rac-(4aR,7aS)-4-benzyl-octahydropyrrolo[3,4-b]morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | cis-8-Benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane | HCID 53682667 | — |
| Solvent | Water | HCID 962 | — |
| Product | rac-(4aR,7aS)-4-benzyl-octahydropyrrolo[3,4-b]morpholine | HCID 10856960 | — |
Reaction Steps
91 g (0.265 mol) of cis-8-benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane are refluxed overnight with 200 ml of concentrated hydrochloric acid and 140 ml of water. The batch is cooled and the benzoic acid suctioned off. The batch is concentrated to half its original volume, adjusted to alkalinity with potassium carbonate, extracted with chloroform, dried over potassium carbonate, concentrated, and distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05468742 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-e4fddf6a3d634a8ea900c4f13e228d4e |
| Source note | uspto-grants-1995_11 |