Triphenylphosphine → HCID 68884003, compound

Participants

Reaction Steps

To a mixture of [4-[(E)-2-(5-methyl-2-phenyl-4-oxazolyl)ethenyl]phenyl]methanol (0.50 g), methyl 2-(2-hydroxyphenyl)acetate (0.27 g), triphenylphosphine (0.63 g) and tetrahydrofuran (30 mL) was dropwise added a solution (40%, 1.04 g) of diethyl azodicarboxylate in toluene at room temperature, and the mixture was stirred for 15 hrs. To the reaction mixture was added ethyl acetate, the mixture was washed successively with water, a 2N aqueous sodium hydroxide solution and saturated brine, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to give methyl 2-[2-[4-[(E)-2-(5-methyl-2-phenyl-4-oxazolyl)ethenyl]benzyloxy]phenyl]acetate as a pale-yellow oil (0.4-6 g, 66%) from a fraction eluted with ethyl acetate-hexane (1:6, v/v).

Provenance & Evidence