Hydrochloric Acid → HCID 68886211, compound

Participants

Reaction Steps

To a mixture of 2-[2-[4-[[3-methyl-1-(2-pyridyl)-1H-pyrazol-4-yl]methoxy]benzyloxy]-3-pyridyl]acetonitrile (0.30 g) and ethanol (15 mL) was added a 2N aqueous sodium hydroxide solution (10 mL) and the mixture was heated under reflux for 24 hrs. 1N Hydrochloric acid (20 mL) and water were added to the reaction mixture. The precipitated crystals were collected by filtration and dried with air to give crystals (0.23 g, 74%) of 2-[2-[4-[[3-methyl-1-(2-pyridyl)-1H-pyrazol-4-yl]methoxy]benzyloxy]-3-pyridyl]acetic acid. Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 150-151° C.

Provenance & Evidence