Tributylphosphine → HCID 86591573, compound

Participants

Reaction Steps

To a mixture of 4-[methyl(4-phenyl-2-thiazolyl)aminomethyl]benzyl alcohol (1.00 g), methyl 2-(4-hydroxyphenyl)acetate (643 mg), tributylphosphine (1.30 g) and tetrahydrofuran (30 mL) was added 1,1′-(azodicarbonyl)dipiperidine (1.62 g) at room temperature and the mixture was stirred for 16 hrs. The precipitated crystals were filtered off. The filtrate was concentrated and the residue was subjected to silica gel column chromatography to give methyl 4-[4-[methyl(4-phenyl-2-thiazolyl)aminomethyl]benzyloxy]phenylacetate (1.48 g, quantitative) as a yellow oil from a fraction eluted with ethyl acetate-hexane (1:4, v/v).

Provenance & Evidence