Hydrochloric Acid → HCID 86591574, compound

Participants

Reaction Steps

A mixture of methyl 4-[4-[methyl(4-phenyl-2-thiazolyl)aminomethyl]benzyloxy]phenylacetate (510 mg), a 1N aqueous sodium hydroxide solution (2.5 mL), methanol (5 mL) and tetrahydrofuran (10 mL) was stirred at 60° C. for 1 hr. Water was added to the reaction mixture, 1N hydrochloric acid (3 mL) was added to the mixture, and then the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated to give crystals of 4-[4-[methyl(4-phenyl-2-thiazolyl)aminomethyl]benzyloxy]phenylacetic acid. The crystals were recrystallized from diethyl ether-hexane to give colorless prism crystals (427 mg, 87%). melting point: 116-118° C.

Provenance & Evidence