Hydrochloric Acid → HCID 68884315, compound

Participants

Reaction Steps

A mixture of methyl 3-[4-methoxy-3-[(2-phenyl-5-methyl-4-oxazolyl)methoxy]benzyloxy]phenylacetate (420 mg), 1N sodium hydroxide (2 mL), methanol (5 mL) and tetrahydrofuran (5 mL) was stirred at room temperature for 3 hrs. The reaction mixture was poured into water, and the mixture was neutralized with 2N hydrochloric acid to give crystals of 3-[4-methoxy-3-[(2-phenyl-5-methyl-4-oxazolyl)methoxy]benzyloxy]phenylacetic acid. Recrystallization from ethyl acetate gave colorless prism crystals (350 mg, 86%). melting point: 114-115° C.

Provenance & Evidence