反应详情

温度

40 °C

1N Sodium hydroxide-methanol solution (2.4 ml) was added to 2-[2-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-3-pyridyl]acetic acid (1.0 g) and the mixture was heated to 40° C. The obtained solution was allowed to cool and acetone (10 ml) was added. The mixture was stirred at room temperature for 30 min and acetone (5 ml) was further added. The mixture was stirred at room temperature for 1 hr, and under ice-cooling for 1 hr. The precipitated crystals were collected by filtration, washed with acetone (10 ml) ice-cooled in advance, and dried under reduced pressure to give sodium 2-[2-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-3-pyridyl]acetate as white crystals.

1. temperatureto cool
2. stirringThe mixture was stirred at room temperature for 1 hr
3. temperatureunder ice-cooling for 1 hr
4. filtrationThe precipitated crystals were collected by filtration
5. washwashed with acetone (10 ml) ice-
6. temperaturecooled in advance
7. customdried under reduced pressure