HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → ethyl (1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Ethyl 4-bromocinnamate | HCID 141107 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | ethyl (1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylate | HCID 66578655 | — |
Reaction Steps
To a mixture of ethyl 4-bromocinnamate and Pd(OAc)2 (0.05 eq) in methylene chloride (1M) at 0° C. was added dropwise a solution of CH2N2 in ether until the reaction was completed by NMR analysis. The mixture was filtered through a plug of silica gel and concentrated to afford the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07238706B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-933d4361bed34c9782ca889c2bafadfb |
| Source note | uspto-grants-2007_07 |