HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1294370Generated: October 31, 2026
Ethanol → 1-(4-Bromophenyl)cyclopropane-1-carboxylic acid
https://huagongshe.com/reaction/1294370
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(4-Bromophenyl)Cyclopropanecarbonitrile | HCID 2795273 | — |
| Product | 1-(4-Bromophenyl)cyclopropane-1-carboxylic acid | HCID 16227966 | — |
Reaction Steps
A mixture of nitrile (1 eq) from step 1, NaOH 25% (12 eq) in EtOH (0.5M) was heated to 100° C. for 5 h. The mixture was cooled to rt, quenched with AcOH and diluted with ether. The combined organic extracts were washed with brine, dried over MgSO4, filtered and concentrated. Flash chromatography (hexane:EtOAc, 90:10 to 50:50) afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07238706B2 |
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| Source dataset | uspto-grants-2007_07 |
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| ORD ID | ord-734a511db9fb4188b3c8b398efa69488 |
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| Source note | uspto-grants-2007_07 |
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