反应详情

温度

80 °C

A mixture of acid from step 2 (1 eq), amide from step 1 (1 eq), Na2CO3 (3.5 eq.; 2M in H2O), Pd(PPh3)4 (0.15 eq.) in n-propanol-DMF (1:1, 0.1M) was stirred at 80° C. for 2 h. The mixture was cooled to rt, quenched with brine and diluted with EtOAc. The organic extracts were washed with brine, dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (CHCl3:THF; 50:50), triturated in ether/acetone and then isolated by filtration to afford the title compound as a solid.

1. temperatureThe mixture was cooled to rt
2. customquenched with brine
3. additiondiluted with EtOAc
4. washThe organic extracts were washed with brine
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated
8. customThe residue was purified by flash chromatography (CHCl3:THF; 50:50)
9. customtriturated in ether/acetone
10. customisolated by filtration